Tumor necrosis is associated with increased αvβ3 expression and poor prognosis in nodular cutaneous melanomas
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Cellular localization of CIP2A determines its prognostic impact in superficial spreading and nodular melanoma
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an important oncogene contributing to cancer progression partially by regulating cMYC and AKT. We examined CIP2A expression in cutaneous melanomas, its association with clinicopathological parameters and mapped molecular mechanisms regulated by CIP2A in vitro. CIP2A expression was analyzed by immunohistochemistry in 17 nevi, 132 primary m...
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تاریخ انتشار 2008